Research areas

Explore our various research
interests and applications.
Focal Adhesion on hMSCs

Stem Cell and Nanotopography Interaction

How does nano-scale surface features significantly change the cell behaviour and cell fate?
We aim to obtain an understanding of the underlying mechanistic of the topography-induced cell behavior through the study of the nanotopography-induced changes in focal adhesion formation and the synergistic effect of nanotopographical, biochemical and substrate stiffness in directing stem cell differentiation.
Neuronal Markers on Nanopatterened PDMS

Applications of Nanotopography in Neuronal Regeneration

Nanotopography showed significant influence on human mesenchymal stem cell (hMSC) and human embryonic stem cell behavior. Our studies showed that hMSC aligned and elongated along the axis of the gratings. Expression of neuronal markers and upregulation of neuronal gene marker were detected.
We have also shown that the influence of nanotopography on proliferation and differentiation is more significant compared to micro-topography
Nanotopographical cues can be incorporated into neural tissue engineering scaffold design, serving both as a differentiation cue and conduct guidance for axon regeneration.
Cornea Structure

Layered Reconstruction of Cornea

Cornea is a highly organized tissue with distinct structure in each of the corneal epithelial, stromal and endothelial layers. Nano-structures play an important role in the functional and structural support of these layers.
We hypothesize that nano-structured substrate can enhance cell-substratum interaction and provide optimal support for a cornea substitute.

Vascular Repair with a Combination of Nanotopography and Stem Cells

Cardiovascular disease is the number one cause of death and disability in developed countries. Tissue engineering and regenerative medicine, which aim to repair and / or regenerate damaged tissue by mimicking the natural functional microenvironment, will be a promising solution to the problem. As the underlying cause of most cardiovascular diseases is related to atherosclerosis, we aim to address the root of the problem by
  1. Engineering vascular grafts for vascular replacement and
  2. Vascular repair using stem cells.